Combined 5th Oberley Symposium-HCCC Retreat,
June 15-16, 2022, Iowa City, Iowa

Wednesday, June 15th

7:30 AM Arrival, Registration, and poster set up
8:00 – 8:15 AM Welcome – George Weiner, M.D. Director, Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics

8:15 – 9:45 AM Holden Comprehensive Cancer Center Presentations (15 mins ea.)

  • Amira Zaher, Graduate Research Assistant Pharmacological ascorbate selectively enhances NSCLC response to immune checkpoint inhibitor therapy and chemo-radiation in an iron-dependent manner
  • Eliza Steere, Graduate Research Assistant Challenges and Opportunities Implementing Evidence-Based Intervention
  • Amanda Pope, Graduate Research Assistant Resistance to Pharmacological Ascorbate in Pancreatic Cancer
  • Jyoti Arora, Graduate Research Assistant Enhancement of NK cell mediated ADCC using anti-CD3 based bispecific antibody in multiple myeloma
  • Michael O’Rourke, Ph.D. Identifying Patient Requirements for Personal Health Record Software for Neuroendocrine Tumors
  • Sarina Murray, Graduate Research Assistant Restore Functional Progesterone Receptor Expression in Endometrial Cancer

9:45 – 10:00 AM      Break

  • Zhijie Li, Graduate Research Assistant The Influence of SUMOylation on Transcriptional Regulation by ETV1 in Breast Cancer
  • Wade Gutierrez, Graduate Research Assistant Augmenting chemotherapy with low-dose decitabine through an immune-independent mechanism
  • Dane Tow, Student Laboratory Assistant A Genetically Encoded Sensor for Studying Serotonin Metabolism in Neuroendocrine Cancer
  • Khaliunaa Bayanbold, Graduate Research Assistant Ferritin Heavy Chain (Ft-H) Limits Iron Availability and Promotes Replication Stress in Lung Cancer Cell
  • Liz Orton, Program Coordinator for Iowa Cancer Consortium How Collaboration, Focus, and Determination Brought About Policy, Systems, and Environmental (PSE) Change with The Gail Orcutt School Radon Safety Bill
  • Sabrish Ayyappan, M.D. Phase 0 study to evaluate role of T cells in NK cell mediated antibody dependent cellular cytotoxicity (ADCC) of lymphoma

11:30 – 1:30 PM Lunch Break and poster viewing, Coral Ballrooms, Salon C-E

Joint Session: Cancer Redox Biology and Therapy 1:30 PM – 5:30 PM  

Chairs (Douglas Spitz, Corinne Griguer)

Location: Hyatt Regency, Coral Ballrooms A-B

1:30 – 1:55 PM        Jian Jian Li MD, PhD; HCCC, University of California Davis,
Reprogramming of the Tumor Microenvironment during Radiotherapy”

1:55 – 2:20 PM:       Barry London, MD, PhD; HCCC, University of Iowa,
Understanding and Preventing Cardiac Damage during Radiotherapy

2:20 – 2:30 PM:      Break and poster viewing

2:30 – 2:55 PM:       Corinne Griguer, PhD; HCCC, University of Iowa,
Chlorpromazine Inhibition of COX4-1 containing Cytochrome C Oxidase to Treat Chemoresistant Glioma”.

2:55 – 3:20 PM:       Mitchell Coleman, PhD; HCCC, University of Iowa,
“Hydrogen Peroxide Disrupts Adipocyte Differentiation: a Late Opportunity for Antioxidants against Fibrosis after Radiotherapy?””

3:20 – 3:30 PM:       Break and poster viewing

3:30 – 4:30 PM:       Cancer Colloquium: James Doroshow, MD, National Cancer Institute, Bethesda, MD, “Role of Reactive Oxygen Species in the Cytotoxicity of Selected Anticancer Compounds

4:30 – 5:30 PM:       Translational Oncology Roundtables:

Track 1: Clinical Development and Medical Applications of SOD Mimetic Drugs – ( Douglas Spitz PhD, Becky Oberley-Deegan PhD, John Buatti, MD)

Track 2: Clinical studies employing Vitamin C infusion, or pharmacological ascorbate administration, as an adjuvant to chemo-radiotherapy. (Garry Buettner PhD, Bryan Allen MD PhD, Varun Monga MD)

5:30 – 6:30 PM:       Wine and Cheese Social, Hyatt Regency Hotel, TBA (Dinner on your own or in groups in and around Iowa River Landing area)

Thursday, June 16th

7:45 AM – 12:00 PM: Registration and Poster Set up

Session Two: Redox Signaling and Disease Mechanisms 8:00 AM – 1:15 PM
Location: Marriott Room TBA
Chairs (Bryan G. Allen, Corinne Griguer)

7:50 – 8:00 AM:       Douglas Spitz, PhD, Director- Free Radical & Radiation Biology Program, University of Iowa “Welcome and Opening Remarks

8:00 – 8:25 AM:       Isabella Grumbach, MD, PhD; HCCC, University of Iowa,
Protecting Mitochondrial Function to Prevent (Cardio)vascular Toxicity of Radiotherapy

8:25 – 8:50 AM:       Lisa A. Ridnour, PhD; Center for Cancer Research, National Cancer Institute,
Adjuvant COX Inhibition Augments STING Signaling and Cytolytic T Cell Infiltration in Irradiated 4T1 TNBC Tumors”

8:50 – 9:50 AM:       Special Seminar: Leslie Poole, PhD; Wake Forest University School of Medicine,
Peroxiredoxin structures and dynamics tailored to their roles in redox signaling and defense

9:50 – 10:00 AM      Break

10:00 – 10:25 AM:  Ehab Sarsour, PhD; Kansas City University of Medicine and Biosciences
Lipolysis regulates the chronological life span of aging fibroblasts”

10:25 – 10:50 AM:  Eric Kelley, PhD; West Virginia University,
Heme-Induced Elevation in Circulating Xanthine Oxidase is a Protective Response

10:50 – 11:15 AM:  Break and poster viewing

11:15 – 12:15 PM:   Plenary Lecture: Paul Schumacker, PhD; Northwestern University,
Redox Signaling During Hypoxia in Mammalian Cells

12:15 – 1:15 PM:     Lunch break and poster view

Session Three: Oxygen Biology and Redox Balance 1:15 PM – 4:30 PM
Location: Hyatt Regency Room TBA Chairs (Ehab H. Sarsour, Becky Oberley)

1:15 – 1:40 PM:       Adam J. Case, PhD; Texas A&M University,
Mitochondrial superoxide in T-lymphocytes: Implications for post-traumatic stress disorder

1:40 – 2:05 PM:       Luksana Chaiswing, PhD; University of  Kentucky,
Targeting Mitochondrial Redox State to Enhance Prostate Cancer

2:05 – 2:30 PM:       Break

2:30 – 2:55 PM:       Michael Hitchler, PhD; Kaiser Permanente, Los Angeles, CA,
The epigenetic and morphogenetic effects of molecular oxygen and its derived reactive species in development

2:55 – 3:20 PM:       Frederick Domann, PhD; University of Iowa,
Succinate Accumulation Links Mitochondrial MnSOD Depletion to Aberrant Nuclear DNA Methylation and Altered Cell Fate

3:20 – 4:20 PM:       Keynote Address: Mark Dewhirst, DVM, PhD; Duke University;
Implications of Cyclic Hypoxia for Tumor Metabolism and Response to Therapy

4:20 – 4:30 PM:       Douglas R. Spitz, PhD; University of Iowa, Closing Remarks

4:30 – 6:30 PM:       Cash Bar at The Hyatt Regency

6:30 PM:        Closing Banquet Dinner Party at The Hyatt; Speaker: Kathleen Oberley,
“The Life and Times of Redox Pioneers Larry and Terry Oberley

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